In schizophrenia patients, vmPFC activation correlated negatively with implicit aberrant salience attribution.

In the self-reference task, schizophrenia patients showed reduced activation in the ventromedial prefrontal cortex (vmPFC), but individuals with subclinical delusional ideation did not differ from healthy controls. Schizophrenia patients displayed increased aberrant salience attribution compared with healthy controls and individuals with subclinical delusional ideation, while the latter exhibited intermediate aberrant salience scores. The correlation between self-referential processing and aberrant salience attribution was tested. Participants performed a self-reference task during fMRI in which they had to apply neutral trait words to them or to a public figure.

Aberrant salience was assessed behaviorally in terms of reaction times to task irrelevant cues. Twenty-nine schizophrenia patients, 24 healthy individuals with subclinical delusional ideation, and 50 healthy individuals participated in this study. We investigated the neural correlates of self-referential processing, aberrant salience attribution, and the relationship between these 2 measures across the psychosis continuum. Self-referential processing relies on the activation of cortical midline structures which was demonstrated to be impaired in psychosis. The aberrant salience hypothesis assumes that positive symptoms arise from an attribution of salience to irrelevant stimuli accompanied by the feeling of self-relevance.

5 Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaption', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Ī dysfunctional differentiation between self-relevant and irrelevant information may affect the perception of environmental stimuli as abnormally salient.

4 Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Faculty of Medicine, Universität Leipzig, Leipzig, Germany.

3 Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.

1 Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany 2 Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Aberrant crossover definition